Spheroids Composed of Reaggregated Neonatal Porcine Islets and Human Endothelial Cells Accelerate Development of Normoglycemia in Diabetic Mice

Spheroids Composed of Reaggregated Neonatal Porcine Islets and Human Endothelial Cells Accelerate Development of Normoglycemia in Diabetic Mice

The engraftment of transplanted islets depends on the rapid establishment of a novel vascular network. The present study evaluated the effects of cord blood-derived blood outgrowth endothelial cells (BOECs) on the viability of neonatal porcine islets (NPIs) and the post-transplant outcome of grafted...

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Main Authors: Mohsen Honarpisheh, Yutian Lei, Antonia Follenzi, Alessia Cucci, Cristina Olgasi, Ekaterine Berishvili, Fanny Lebreton, Kevin Bellofatto, Lorenzo Piemonti, Antonio Citro, Francesco Campo, Cataldo Pignatelli, Olivier Thaunat, Elisabeth Kemter, Martin Kraetzl, Eckhard Wolf, Jochen Seissler, Lelia Wolf-van Buerck, VANGUARD Consortium
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
xenotransplantation
neonatal porcine islet-like cell clusters
reaggregated cell clusters
blood outgrowth endothelial cells
Online Access:https://www.mdpi.com/2073-4409/14/5/366
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