A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity.

Due to the inexorable invasion of our hospitals and communities by drug-resistant bacteria, there is a pressing need for novel antibacterial agents. Here we report the development of a sensitive and robust but low-tech and inexpensive high-throughput metabolic screen for novel antibiotics. This scre...

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Bibliographic Details
Main Authors: Patrick Ymele-Leki, Shugeng Cao, Jared Sharp, Kathleen G Lambert, Alexander J McAdam, Robert N Husson, Giselle Tamayo, Jon Clardy, Paula I Watnick
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0031307&type=printable
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