Female glucagon receptor knockout mice are prone to steatosis but resistant to weight gain when fed a MASH‐promoting GAN diet and a high‐fat diet

Female glucagon receptor knockout mice are prone to steatosis but resistant to weight gain when fed a MASH‐promoting GAN diet and a high‐fat diet

Abstract Glucagon is secreted from the pancreatic alpha cells and regulates not only hepatic glucose production, but also hepatic lipid and amino acid metabolism. Thus, glucagon provides a switch from hepatic glucose and lipid storage towards lipid and amino acid breakdown fueling glucose production...

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Main Authors: Katrine D. Galsgaard, Emilie Elmelund, Jenna E. Hunt, Mark M. Smits, Trisha J. Grevengoed, Christina Christoffersen, Nils J. Færgeman, Jesper Havelund, Nicolai J. Wewer Albrechtsen, Jens J. Holst
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Physiological Reports
Subjects:
cholesterol
glucagon
high‐fat diet
steatosis
triglycerides
Online Access:https://doi.org/10.14814/phy2.70235
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https://doi.org/10.14814/phy2.70235

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