p53-regulated SESN1 and SESN2 regulate cell proliferation and cell death through control of STAT3

p53-regulated SESN1 and SESN2 regulate cell proliferation and cell death through control of STAT3

Abstract Sestrin1 and Sestrin2 (SESN1&2) are evolutionarily conserved, stress-responsive proteins that regulate cell growth and viability. The primary target of Sestrins is the mTORC1 protein kinase, an activator of anabolic processes and an autophagy inhibitor. Our previous studies showed that...

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Bibliographic Details
Main Authors: Alexander Haidurov, Andrei O. Zheltukhin, Anastasiya V. Snezhkina, George S. Krasnov, Anna V. Kudryavtseva, Andrei V. Budanov
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cell Communication and Signaling
Subjects:
SESN1/2
STAT3
Lung cancer
Cell death
Online Access:https://doi.org/10.1186/s12964-025-02104-3
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https://doi.org/10.1186/s12964-025-02104-3

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