Integrating Sequence- and Structure-Based Similarity Metrics for the Demarcation of Multiple Viral Taxonomic Levels

Integrating Sequence- and Structure-Based Similarity Metrics for the Demarcation of Multiple Viral Taxonomic Levels

Viruses exhibit significantly greater diversity than cellular organisms, posing a complex challenge to their taxonomic classification. While primary sequences may diverge considerably, protein functional domains can maintain conserved 3D structures throughout evolution. Consequently, structural homo...

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Bibliographic Details
Main Authors: Igor C. dos Santos, Rebecca di Stephano de Souza, Igor Tolstoy, Liliane S. Oliveira, Arthur Gruber
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Viruses
Subjects:
viral classification
viral taxonomy
taxa demarcation
sequence similarity
protein structure similarity
Online Access:https://www.mdpi.com/1999-4915/17/5/642
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