Assessing HIV-1 subtype C infection dynamics, therapeutic responses and reservoir distribution using a humanized mouse model

Assessing HIV-1 subtype C infection dynamics, therapeutic responses and reservoir distribution using a humanized mouse model

IntroductionWhile HIV-1 subtype C (HIV-1C) is the most prevalent and widely distributed subtype in the HIV pandemic, nearly all current prevention and therapeutic strategies are based on work with the subtype B (HIV-1B). HIV-1C displays distinct genetic and pathogenic features from that of HIV-1B. T...

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Main Authors: Snehal Kaginkar, Leila Remling-Mulder, Ashashree Sahoo, Tejaswini Pandey, Pranay Gurav, Jyoti Sutar, Amit Kumar Singh, Ella Barnett, Sivasankar Panickan, Ramesh Akkina, Vainav Patel
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
humanized mice for HIV-1C
HIV subtype C infection dynamics in humanized mice
anti-retroviral therapy for HIV-1C
drug resistance mutations
HIV-1C tissue reservoir
treatment interruption
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1552563/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1552563/full

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