A Type I IFN-Inducing Oncolytic Virus Improves NK Cell-Mediated Killing of Tumor Cells In Vitro Through Multiple Mechanisms

A Type I IFN-Inducing Oncolytic Virus Improves NK Cell-Mediated Killing of Tumor Cells In Vitro Through Multiple Mechanisms

Natural killer (NK) cell adoptive immunotherapy is a promising therapeutic approach in which NK cells perform targeted lysis of tumor cells. Oncolytic viruses are also effective cancer therapeutic agents due to their ability to selectively target and kill tumor cells. Combination therapies that inte...

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Bibliographic Details
Main Authors: Elisabeth M. Shiffer, Jeremiah L. Oyer, Alicja J. Copik, Griffith D. Parks
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Viruses
Subjects:
natural killer cells
parainfluenza virus 5
oncolytic virus
type 1 interferon
immunotherapeutic
Online Access:https://www.mdpi.com/1999-4915/17/7/897
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