Increased thrombin generation in kidney transplant recipients with donor-specific antibodies directed against human leukocyte antigens

Increased thrombin generation in kidney transplant recipients with donor-specific antibodies directed against human leukocyte antigens

IntroductionThe development of de novo anti-HLA donor specific antibodies (DSAs) is associated with poor outcomes in kidney transplant recipients. It is surmised that an interaction between DSAs and the graft endothelium cause tissue injury, however, the exact underlying pathomechanism and optimal m...

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Main Authors: Linda Lóczi, Réka P. Szabó, Rita Orbán-Kálmándi, Rebeka Hodossy-Takács, Anikó Szilvási, Zoltán Szalai, Gábor Nagy, Péter Antal-Szalmás, Balázs Nemes, Zsuzsa Bagoly
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Immunology
Subjects:
antibody-mediated rejection
donor specific antibody
kidney transplantation
thrombin generation
hemostasis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1407407/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1407407/full

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