Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG1 antibodies

Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG1 antibodies

Bispecific antibodies, including bispecific IgG, are emerging as an important new class of antibody therapeutics. As a result, we, as well as others, have developed engineering strategies designed to facilitate the efficient production of bispecific IgG for clinical development. For example, we have...

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Bibliographic Details
Main Authors: Wen-Ting K. Tsai, Yinyin Li, Zhaojun Yin, Peter Tran, Qui Phung, Zhenru Zhou, Kun Peng, Dan Qin, Sien Tam, Christoph Spiess, Jochen Brumm, Manda Wong, Zhengmao Ye, Patrick Wu, Sivan Cohen, Paul J. Carter
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Anti-drug antibodies
bispecific antibody
ex vivo T cell assay
immunogenicity
in silico prediction
knobs-into-holes
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2362789
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https://www.tandfonline.com/doi/10.1080/19420862.2024.2362789

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