Chemoproteomics unveils Sofalcone targeting ribosomal proteins to inhibit protein synthesis in Staphylococcus aureus

Chemoproteomics unveils Sofalcone targeting ribosomal proteins to inhibit protein synthesis in Staphylococcus aureus

Abstract The escalating threat of antibiotic resistance, particularly in Staphylococcus aureus (including methicillin-resistant strains, MRSA), underscores the urgent need for novel therapeutics. Sofalcone (Sof), a chalcone derivative from Sophora subprostrata with established anti-inflammatory and...

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Bibliographic Details
Main Authors: Lirun Zhou, Ying Zhang, Ruishen Zhuge, Liqiong Wu, Zheng Chu, Ang Ma, Peng Gao, Yin Kwan Wong, Junzhe Zhang, Xin Peng, Peili Wang, Jigang Wang, Huan Tang
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Molecular Biomedicine
Subjects:
Sofalcone
Staphylococcus aureus
Chemoproteomics
Ribosomal proteins
Antibiotics
Drug-resistance
Online Access:https://doi.org/10.1186/s43556-025-00269-4
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https://doi.org/10.1186/s43556-025-00269-4

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