Structure–Activity Relationship Studies in a Series of 2-Aryloxy-<i>N</i>-(pyrimidin-5-yl)acetamide Inhibitors of SLACK Potassium Channels

Structure–Activity Relationship Studies in a Series of 2-Aryloxy-<i>N</i>-(pyrimidin-5-yl)acetamide Inhibitors of SLACK Potassium Channels

Epilepsy of infancy with migrating focal seizures (EIMFS) is a rare, serious, and pharmacoresistant epileptic disorder often linked to gain-of-function mutations in the <i>KCNT1</i> gene. <i>KCNT1</i> encodes the sodium-activated potassium channel known as SLACK, making small...

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Bibliographic Details
Main Authors: Nigam M. Mishra, Brittany D. Spitznagel, Yu Du, Yasmeen K. Mohamed, Ying Qin, C. David Weaver, Kyle A. Emmitte
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
SLACK
<i>KCNT1</i>
K<sub>Na</sub>1.1
Slo2.2
CNS
EIMFS
Online Access:https://www.mdpi.com/1420-3049/29/23/5494
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