L1, a 3,3′-diindolylmethane-derivative, induced ER stress-mediated apoptosis and suppressed growth through the FLI1/AKT pathway in erythroleukemia HEL cells

L1, a 3,3′-diindolylmethane-derivative, induced ER stress-mediated apoptosis and suppressed growth through the FLI1/AKT pathway in erythroleukemia HEL cells

Introduction3,3′-Diindolylmethane (DIM) is a major phytochemical product derived from ingestion of cruciferous vegetables. As an effective cancer chemopreventive agent, DIM has been used in preclinical and clinical trials. Recently, our group synthesized and modified a novel DIM derivative, L1, and...

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Bibliographic Details
Main Authors: Yi Kuang, Yong Jian, Dinghuan Wang, Lihao Bai, Kunlin Yu, Chunlin Wang, Wuling Liu, Sheng Liu, Wan Li, Yaacov Ben-David, Xiao Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
erythroleukemia
3,3′-diindoylmethane derivatives
endoplasmic reticulum stress-mediated apoptosis
FLI1
Hsp70
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1564199/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1564199/full

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