ALKBH3‐Mediated M1A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M1A and M6A RNA Methylation

ALKBH3‐Mediated M1A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M1A and M6A RNA Methylation

Abstract Epigenetic modifications serve as crucial molecular switches for pathological fibrosis; howbeit the role of m1A in this condition remains enigmatic. Herein, it is found that ALKBH3 exerts a pro‐fibrotic effect in pathological skin fibrosis by reshaping N6‐methyladenosine (m6A) RNA modificat...

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Bibliographic Details
Main Authors: Liying Tu, Shuchen Gu, Ruoqing Xu, En Yang, Xin Huang, Hsin Liang, Shenying Luo, Haizhou Li, Yixuan Zhao, Tao Zan
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
ALKBH3
fibroblast
METTL3
pathological skin fibrosis
RNA methylation
Online Access:https://doi.org/10.1002/advs.202417067
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https://doi.org/10.1002/advs.202417067

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