Positive coactivator PC4 shows dynamic nucleolar distribution required for rDNA transcription and protein synthesis

Positive coactivator PC4 shows dynamic nucleolar distribution required for rDNA transcription and protein synthesis

Abstract The nucleolus is the site of rDNA transcription and ribosome biogenesis. Alterations in nucleolar function and architecture correlate with drastic heterochromatin rearrangement and global changes in gene expression. However, the precise mechanism that connects nucleolar function to heteroch...

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Bibliographic Details
Main Authors: Stephanie Kaypee, Kyoko Ochiai, Hiroki Shima, Mitsuyo Matsumoto, Mahabub Alam, Tsuyoshi Ikura, Tapas K. Kundu, Kazuhiko Igarashi
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cell Communication and Signaling
Subjects:
Heterochromatin
Nucleolus
Ribosomal DNA
Ribosome
B cells
Lysine acetyltransferase
Online Access:https://doi.org/10.1186/s12964-025-02238-4
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https://doi.org/10.1186/s12964-025-02238-4

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