Inhibition of eEF2 kinase ameliorates hepatic injury induced by ACR through regulation of the MAPK pathway

Inhibition of eEF2 kinase ameliorates hepatic injury induced by ACR through regulation of the MAPK pathway

Background and aims: Acrylamide (ACR) induces hepatotoxicity, yet its underlying mechanisms remain incompletely understood. Our prior proteomic analysis of serum from occupationally ACR-exposed individuals identified significantly elevated levels of eukaryotic elongation factor 2 (eEF2). Given that...

Full description

Saved in:
Bibliographic Details
Main Authors: Zhi-Ming Li, Xiao-Li Wang, Hong-Wei Yao, Guo-Bing Yu, Xin-Yu Wang, Ru-Nan Zhang, Xiao-Xiao Hao, Wei-Wei Ma, Yu-Meng Xu, Hong-Qiu Li, Ya-Ting Lei, Fang-Fang Zhao, Cui-Ping Yu, Yong-Hui Wu, Yu-Lin Pan, Sheng-Yuan Wang
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Acrylamide
EEF2K
Hepatic injury
Sphingolipids
MAPK signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325012436
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S0147651325012436

Similar Items