Noninvasive prenatal diagnosis of hemophilia A by a haplotype-based approach using cell-free fetal DNA

Noninvasive prenatal diagnosis of hemophilia A by a haplotype-based approach using cell-free fetal DNA

Aim: We aimed to demonstrate noninvasive prenatal diagnosis (NIPD) of hemophilia A (HA) using a haplotype-based approach. Methods: Two families at risk for HA were recruited for this study. First, maternal haplotypes associated with pathogenic variants were constructed using the genotypes of the mot...

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Bibliographic Details
Main Authors: Chao Chen, Jun Sun, Yun Yang, Lu Jiang, Fengyu Guo, Yaping Zhu, Dan Li, Renhua Wu, Rong Lu, Mei Zhao, Fang Chen, Peixiang Ni, Zhihui He, Zhiyu Peng
Format: Article
Language:English
Published: Taylor & Francis Group 2020-03-01
Series:BioTechniques
Subjects:
factor VIII
haplotype
hemophilia A
noninvasive prenatal diagnosis
targeted sequencing
Online Access:https://www.future-science.com/doi/10.2144/btn-2019-0113
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https://www.future-science.com/doi/10.2144/btn-2019-0113

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