Neuroprotective effects of bone marrow mesenchymal stem cells combined with mannitol on radiation-induced brain injury by regulating autophagy via the PI3K/AKT/mTOR signaling pathway

Neuroprotective effects of bone marrow mesenchymal stem cells combined with mannitol on radiation-induced brain injury by regulating autophagy via the PI3K/AKT/mTOR signaling pathway

Background: Bone marrow mesenchymal stem cells (BMSCs) have demonstrated potential in the treatment of radiation-induced brain injury (RIBI); however, the presence of the blood-brain barrier (BBB) limits their therapeutic efficacy. Additionally, the precise mechanisms behind the use of BMSCs in trea...

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Bibliographic Details
Main Authors: Shichao Pan, Yuxin Wen, Zhanhong Liu, Kaina Xu, Na Zhang, Xingbo Tong, Ye Teng, Xue Song, Xu Tong
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Brain Research Bulletin
Subjects:
Bone marrow mesenchymal stem cells
Blood-brain barrier
Mannitol
Radiation-induced brain injury
Autophagy
PI3K/AKT/mTOR
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923025001388
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