Targeting copper homeostasis: Akkermansia-derived OMVs co-deliver Atox1 siRNA and elesclomol for cancer therapy

Targeting copper homeostasis: Akkermansia-derived OMVs co-deliver Atox1 siRNA and elesclomol for cancer therapy

Cuproptosis, a recently identified form of regulated cell death triggered by excess intracellular copper, has emerged as a promising cytotoxic strategy for cancer therapy. However, the therapeutic efficacy of copper ionophores such as elesclomol (ES) is often hindered by cellular copper homeostasis...

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Bibliographic Details
Main Authors: Muhammad Hamza, Shuai Wang, Hao Wu, Jiayi Sun, Yang Du, Chuting Zeng, Yike Liu, Kun Li, Xili Zhu, Huiying Liu, Lin Chen, Motao Zhu
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Cuproptosis
Elesclomol
Antioxidant protein 1 siRNA
Outer membrane vesicle
Akkermansia muciniphila
Tumor microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525001480
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