A systematic review of the causes and consequences of spreading depolarization in neuroinflammation; implications for neurovascular disorders

A systematic review of the causes and consequences of spreading depolarization in neuroinflammation; implications for neurovascular disorders

Abstract Background Spreading depolarization (SD) is a wave of neuronal and glial depolarization observed in various neurological conditions, including stroke, traumatic brain injury, subarachnoid haemorrhage, and migraine aura. This depolarization disrupts ion homeostasis, creating high energy dema...

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Bibliographic Details
Main Authors: Faheem Anwar, Olivia Grech, Caroline W. Mugo, James A. Roberts, Jessica C. Hubbard, Chloe N. Thomas, Alexandra J. Sinclair, Lisa J. Hill
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Neuroinflammation
Subjects:
Spreading depolarization
Spreading depression
Inflammation
Neuroinflammation
Migraine
Neurovascular disorders
Online Access:https://doi.org/10.1186/s12974-025-03503-6
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https://doi.org/10.1186/s12974-025-03503-6

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