Clinical Features and T‐Cell Repertoire of Chronic Myeloid Leukemia Patients Who Attempt Discontinuation of Tyrosine Kinase Inhibitors: The ISAC‐TFR Study

Clinical Features and T‐Cell Repertoire of Chronic Myeloid Leukemia Patients Who Attempt Discontinuation of Tyrosine Kinase Inhibitors: The ISAC‐TFR Study

ABSTRACT Background While tyrosine kinase inhibitor (TKI) discontinuation is an established therapeutic goal, up to 60% of patients relapse after the first attempt. The feasibility of a second or third attempt at TKI discontinuation remains uncertain. Immune surveillance, particularly T‐cell and nat...

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Main Authors: Hiroshi Ureshino, Yukio Nakamura, Yemima Budirahardja, Iwao Nozawa, Keisuke Kidoguchi, Kazuharu Kamachi, Shinya Kimura
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Cancer Medicine
Subjects:
T‐cell immunology
T‐cell receptor repertoire
treatment‐free remission
tyrosine kinase inhibitorchronic myeloid leukemia
Online Access:https://doi.org/10.1002/cam4.71142
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https://doi.org/10.1002/cam4.71142

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