Single‐cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma

Single‐cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma

Abstract Glioblastoma (GBM) remains the most malignant primary brain tumor, with a median survival rarely exceeding 2 years. Tumor heterogeneity and an immunosuppressive microenvironment are key factors contributing to the poor response rates of current therapeutic approaches. GBM‐associated macroph...

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Main Authors: Lise Finotto, Basiel Cole, Wolfgang Giese, Elisabeth Baumann, Annelies Claeys, Maxime Vanmechelen, Brecht Decraene, Marleen Derweduwe, Nikolina Dubroja Lakic, Gautam Shankar, Madhu Nagathihalli Kantharaju, Jan Philipp Albrecht, Ilse Geudens, Fabio Stanchi, Keith L Ligon, Bram Boeckx, Diether Lambrechts, Kyle Harrington, Ludo Van Den Bosch, Steven De Vleeschouwer, Frederik De Smet, Holger Gerhardt
Format: Article
Language:English
Published: Springer Nature 2023-10-01
Series:EMBO Molecular Medicine
Subjects:
glioblastoma
LGALS1
macrophages
scRNA‐seq
zebrafish avatars
Online Access:https://doi.org/10.15252/emmm.202318144
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https://doi.org/10.15252/emmm.202318144

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