Comprehensive analysis of nasal IgA antibodies induced by intranasal administration of the SARS-CoV-2 spike protein

Comprehensive analysis of nasal IgA antibodies induced by intranasal administration of the SARS-CoV-2 spike protein

Intranasal vaccination is an attractive strategy for preventing COVID-19 disease as it stimulates the production of multimeric secretory immunoglobulin A (IgA), the predominant antibody isotype in the mucosal immune system, at the target site of severe acute respiratory syndrome coronavirus 2 (SARS-...

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Bibliographic Details
Main Authors: Kentarou Waki, Hideki Tani, Eigo Kawahara, Yumiko Saga, Takahisa Shimada, Emiko Yamazaki, Seiichi Koike, Yoshitomo Morinaga, Masaharu Isobe, Nobuyuki Kurosawa
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-05-01
Series:eLife
Subjects:
IgA
SARS-CoV-2
intranasal vaccination
monoclonal antibody
plasma cell
COVID-19
Online Access:https://elifesciences.org/articles/88387
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https://elifesciences.org/articles/88387

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