CNRein: an evolution-aware deep reinforcement learning algorithm for single-cell DNA copy number calling
Abstract Low-pass single-cell DNA sequencing technologies and algorithmic advancements have enabled haplotype-specific copy number calling on thousands of cells within tumors. However, measurement uncertainty may result in spurious CNAs inconsistent with realistic evolutionary constraints. We introd...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-04-01
|
| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-025-03553-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|