TIGIT+ CD4+ regulatory T cells enhance PD-1 expression on CD8+ T cells and promote tumor growth in a murine ovarian cancer model

TIGIT+ CD4+ regulatory T cells enhance PD-1 expression on CD8+ T cells and promote tumor growth in a murine ovarian cancer model

Abstract Immune checkpoint-based immunotherapy has shown limited efficacy in the treatment of ovarian cancer. In recent years, the emergence of immune checkpoint co-targeting therapies, led by the combination targeting of TIGIT and FAK, has shown promise in ovarian cancer treatment. Our preliminary...

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Bibliographic Details
Main Authors: Fengzhen Chen, Yanying Xu, Xiangyu Liu, Na Dong, Lei Tian
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Ovarian Research
Subjects:
TIGIT
Ovarian cancer
Regulatory T cell
PD-1
Online Access:https://doi.org/10.1186/s13048-024-01578-y
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https://doi.org/10.1186/s13048-024-01578-y

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