Impact of prenatal Di(2-ethylhexyl) phthalate exposure on pubertal development in female offspring rats: A focus on ERα-Mediated IGF-1/NKB crosstalk in the hypothalamus

Impact of prenatal Di(2-ethylhexyl) phthalate exposure on pubertal development in female offspring rats: A focus on ERα-Mediated IGF-1/NKB crosstalk in the hypothalamus

Abstract Di(2-ethylhexyl) phthalate (DEHP), renowned for its efficacy in enhancing the pliability of plastic products, serves predominantly as a plasticizer and additive in the plastics industry. A growing body of research in both animal models and human populations has elucidated that the maternal...

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Bibliographic Details
Main Authors: Xiuying Li, Chunyan Li, Qingjie Li, Yuzhuo Wang, Modi Yang, Zhongsheng Zhou, Bo Zhang, Hang Li, Yingying Xu, Te Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Di(2-ethylhexyl) phthalate
Prenatal exposure
Precocious puberty
Hypothalamus
Online Access:https://doi.org/10.1038/s41598-025-08253-2
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https://doi.org/10.1038/s41598-025-08253-2

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