Salmonella Typhi gut invasion drives hypoxic immune subsets associated with disease outcomes

Salmonella Typhi gut invasion drives hypoxic immune subsets associated with disease outcomes

Abstract Salmonella Typhi (S. Typhi), the causative agent of typhoid disease, remains a major public health concern. Owing to the human-restricted nature of S. Typhi, studies of typhoid pathogenesis in animal models are limited to a murine non-typhoidal pathogen. More recently, human challenge model...

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Main Authors: Noa Bossel Ben-Moshe, Shelly Hen-Avivi, Liron Levy Efrati, Leia Veinman, Jennifer Hill, Daniel O’Connor, Marije Verheul, Lisa Stockdale, Florence McLean, Andrew J. Pollard, Roi Avraham
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62136-8
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https://doi.org/10.1038/s41467-025-62136-8

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