Exosomes derived from IFNγ-stimulated mesenchymal stem cells protect photoreceptors in RCS rats by restoring immune homeostasis through tsRNAs

Exosomes derived from IFNγ-stimulated mesenchymal stem cells protect photoreceptors in RCS rats by restoring immune homeostasis through tsRNAs

Abstract Background Retinitis pigmentosa is a neurodegenerative disease with major pathologies of photoreceptor apoptosis and immune imbalance. Mesenchymal stem cells (MSCs) have been approved for clinical application for treating various immune-related or neurodegenerative diseases. The objective o...

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Bibliographic Details
Main Authors: Luodan A, Linghui Qu, Juncai He, Lingling Ge, Hui Gao, Xiaona Huang, Tianjing You, Hong Gong, Qingle Liang, Siyu Chen, Jing Xie, Haiwei Xu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cell Communication and Signaling
Subjects:
Exosomes
Retinitis pigmentosa
Mesenchymal stem cells
Inflammatory regulation
Immunomodulation
Online Access:https://doi.org/10.1186/s12964-024-01920-3
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https://doi.org/10.1186/s12964-024-01920-3

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