From genomics to treatment: overcoming pan-drug-resistant Klebsiella pneumoniae in clinical settings

From genomics to treatment: overcoming pan-drug-resistant Klebsiella pneumoniae in clinical settings

IntroductionThe spread pan-drug resistant pathogens pose a critical challenge to current therapies, resulting in high mortality and necessitating alternative approaches.MethodsWe report pan-drug resistant Klebsiella pneumoniae isolates from five patients in a single hospital, including resistance to...

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Main Authors: Fernando Pasteran, Juan Manuel De Mendieta, Natalia Pujato, Gina Dotta, Lisandro J. González, Mabel Rizzo, Alejandra Fernández, Paola Ceriana, Lucia Maccari, Melina Rapoport, Sonia Gómez, Celeste Lucero, María Alejandra Menocal, Ezequiel Albornoz, Denise De Belder, Marcelo Radisic, Alejandro J. Vila, Alejandra Corso
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
multi-drug resistance
emerging pathogens
Klebsiella pneumoniae
pan-drug resistance
aztreonam-avibactam
NDM carbapenemase
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1570278/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1570278/full

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