Disulfide-mediated tetramerization of TRAP1 fosters its antioxidant and pro-neoplastic activities

Disulfide-mediated tetramerization of TRAP1 fosters its antioxidant and pro-neoplastic activities

The mitochondrial chaperone TRAP1 exerts protective functions under diverse stress conditions. It induces metabolic rewiring and safeguards cancer cells from oxidative insults, thereby contributing to neoplastic progression.TRAP1 works as a homodimer, but recent evidence indicated that it forms tetr...

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Main Authors: Fiorella Faienza, Claudio Laquatra, Matteo Castelli, Gianmarco Matrullo, Salvatore Rizza, Federica Guarra, Azam Roshani Dashtmian, Alessia Magro, Paola Giglio, Chiara Pecorari, Lavinia Ferrone, Elisabetta Moroni, Francesca Pacello, Andrea Battistoni, Giorgio Colombo, Andrea Rasola, Giuseppe Filomeni
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Redox Biology
Subjects:
Oxidative stress
Mitochondria
Cysteine
Tumorigenesis
Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001909
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