An inhibitory segment within G-patch activators tunes Prp43-ATPase activity during ribosome assembly

An inhibitory segment within G-patch activators tunes Prp43-ATPase activity during ribosome assembly

Abstract Mechanisms by which G-patch activators tune the processive multi-tasking ATP-dependent RNA helicase Prp43 (DHX15 in humans) to productively remodel diverse RNA:protein complexes remain elusive. Here, a comparative study between a herein and previously characterized activators, Tma23 and Pxr...

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Main Authors: Daniela Portugal-Calisto, Alexander Gregor Geiger, Julius Rabl, Oscar Vadas, Michaela Oborská-Oplová, Jarosław Mazur, Federica Richina, Purnima Klingauf-Nerurkar, Erich Michel, Alexander Leitner, Daniel Boehringer, Vikram Govind Panse
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54584-5
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https://doi.org/10.1038/s41467-024-54584-5

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