Discovery of LAH-1 as potent c-Met inhibitor for the treatment of non-small cell lung cancer

Discovery of LAH-1 as potent c-Met inhibitor for the treatment of non-small cell lung cancer

Dysregulated HGF/c-Met pathway has been implicated in multiple human cancers and has become an attractive target for cancer intervention. Herein, we report the discovery of N-(3-fluoro-4-((2-(3-hydroxyazetidine-1-carboxamido)pyridin-4-yl)oxy)phenyl)-1-(4-fluorophenyl)-4-methyl-6-oxo-1,6-dihydropyrid...

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Bibliographic Details
Main Authors: Lijie Sima, Zhongyuan Wang, Ling Yu, Youli Hou, Dongsheng Zhao, Bilan Luo, Weike Liao, Xinfu Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
c-Met
LAH-1
antitumor activity
NSCLC
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2286435
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https://www.tandfonline.com/doi/10.1080/14756366.2023.2286435

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