PPP1R12B inhibits cell proliferation by inducing G0/G1 phase arrest via PAK2/β-catenin axis in hepatocellular carcinoma

PPP1R12B inhibits cell proliferation by inducing G0/G1 phase arrest via PAK2/β-catenin axis in hepatocellular carcinoma

Protein phosphatase 1 regulatory subunit 12B (PPP1R12B) is a regulatory subunit of protein phosphatase 1. While our previous study identified the inhibitory role of PPP1R12B in hepatocellular carcinoma (HCC), the precise molecular mechanisms underlying its anti-proliferative effects remain unclear....

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Main Authors: Yangqianwen Zhang, Shuowu Liu, Mixue Bai, Zihan Zhao, Shan Wang, Meiyu Bao, Jinxia Bao, Siyun Shen, Shuang Lu, Ying Xiong, Gaoxiang Gu, Hongyang Wang, Lei Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
PPP1R12B
PAK2/β-catenin axis
hepatocellular carcinoma
cell proliferation
cell cycle
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1621705/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1621705/full

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