Ruxolitinib Delays Nucleus Pulposus Cell Senescence in Rat Intervertebral Discs

Ruxolitinib Delays Nucleus Pulposus Cell Senescence in Rat Intervertebral Discs

ABSTRACT Background Intervertebral disc degeneration involves aging and senescence of nucleus pulposus cells (NPCs), and JAK/STAT signaling may contribute to this process. The aim of this study was to investigate the therapeutic effect of the JAK2 inhibitor, ruxolitinib, on NPC senescence. Methods C...

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Bibliographic Details
Main Authors: Honggang Hao, Weidong Liang, Shuwen Zhang, Xiaoyu Cai, Abulizi Yakefu, Shutao Gao, Chuanhui Xun, Tao Xu, Rui Cao, Weibin Sheng
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:JOR Spine
Subjects:
JAK2/STAT3 signaling pathway
nucleus pulposus cells
ruxolitinib
senescence
Online Access:https://doi.org/10.1002/jsp2.70044
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https://doi.org/10.1002/jsp2.70044

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