The long-lasting expression of recombinant artLCMV following intraperitoneal administration exerts potent antitumor effects on tumor models of peritoneal carcinomatosis

The long-lasting expression of recombinant artLCMV following intraperitoneal administration exerts potent antitumor effects on tumor models of peritoneal carcinomatosis

Peritoneal carcinomatosis remains a challenging clinical condition with limited therapeutic options. In this study, we evaluated the efficacy of a recombinant artLCMV platform encoding tumor antigens and immune-stimulatory molecules in preclinical models. We analyzed the expression kinetics, biodist...

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Main Authors: Celia Gomar, Aline Risson, Leire Arrizabalaga, Nuria Ardaiz, Virginia Belsue, Adrian Gil-Korilis, Sarah Ahmadi-Erber, Timo Schippers, Ignacio Melero, Klaus K. Orlinger, Fernando Aranda, Henning Lauterbach, Pedro Berraondo
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
4-1BBL
artLCMV vectors
folate receptor alpha (FRα)
gp70
IL12
peritoneal carcinomatosis
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2520266
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https://www.tandfonline.com/doi/10.1080/2162402X.2025.2520266

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