Nerve injury inhibits Oprd1 and Cnr1 transcription through REST in primary sensory neurons

Nerve injury inhibits Oprd1 and Cnr1 transcription through REST in primary sensory neurons

Abstract The transcription repressor REST in the dorsal root ganglion (DRG) is upregulated by peripheral nerve injury and promotes the development of chronic pain. However, the genes targeted by REST in neuropathic pain development remain unclear. The expression levels of four opioid receptor genes...

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Main Authors: Ashok Subedi, Asieh Etemad, Aadhya Tiwari, Yuying Huang, Biji Chatterjee, Samantha M. McLeod, Yungang Lu, DiAngelo Gonzalez, Krishna Ghosh, Mario Sirito, Sanjay K. Singh, Elisa Ruiz, Sandra L. Grimm, Cristian Coarfa, Hui-Lin Pan, Sadhan Majumder
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
REST
Dorsal root ganglion
Chronic pain
Opioid receptors
Cannabinoid CB1 receptor
Therapeutic target
Online Access:https://doi.org/10.1038/s41598-024-74487-1
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https://doi.org/10.1038/s41598-024-74487-1

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