NEK2 Phosphorylates RhoGDI1 to Promote Cell Proliferation, Migration and Invasion Through the Activation of RhoA and Rac1 in Colon Cancer Cells

NEK2 Phosphorylates RhoGDI1 to Promote Cell Proliferation, Migration and Invasion Through the Activation of RhoA and Rac1 in Colon Cancer Cells

Rho guanine nucleotide dissociation inhibitor 1 (RhoGDI1) plays a critical role in regulating the activity of Rho guanosine triphosphatases (GTPases). Phosphorylation of RhoGDI1 dynamically modulates the activation of Rho GTPases, influencing cell proliferation and migration. This study explored the...

Full description

Saved in:
Bibliographic Details
Main Authors: Jeewon Lim, Yo-Sep Hwang, Jong-Tae Kim, Hyang-Ran Yoon, Hyo-Min Park, Jahyeong Han, Taeho Kwon, Kyung-Ho Lee, Hee-Jun Cho, Hee-Gu Lee
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Cells
Subjects:
NEK2
RhoGDI1
Rho GTPase
proliferation
migration
cancer
Online Access:https://www.mdpi.com/2073-4409/13/24/2072
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/2073-4409/13/24/2072

Similar Items