Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection

Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection

Summary: T-dependent germinal center (GC) output, comprising plasma cells and memory B cells (MBCs), is crucial for clearance of Plasmodium infection and protection against reinfection. In this study, we examine the effect of an agonistic antibody targeting 4-1BB (CD137) during experimental malaria....

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Bibliographic Details
Main Authors: Carolina Calôba, Alexandria J. Sturtz, Taylor A. Lyons, Lijo John, Akshaya Ramachandran, Allen M. Minns, Anthony M. Cannon, Justin P. Whalley, Tania H. Watts, Mark H. Kaplan, Scott E. Lindner, Rahul Vijay
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725002992
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http://www.sciencedirect.com/science/article/pii/S2211124725002992

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