Insulin-induced gene 2 alleviates ischemia-reperfusion injury in steatotic liver by inhibiting GPX4-dependent ferroptosis

Insulin-induced gene 2 alleviates ischemia-reperfusion injury in steatotic liver by inhibiting GPX4-dependent ferroptosis

Abstract Hepatic steatosis significantly elevates the vulnerability of the graft to ischemia-reperfusion (I/R) injury during liver transplantation (LT). We investigated the protective role of insulin-induced gene 2 (Insig2) in steatotic liver’s I/R injury and underlying mechanisms. Employing mouse m...

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Main Authors: Yichao Wu, Changbiao Li, Di Lu, Kangchen Chen, Renyi Su, Shengjun Xu, Fengqiang Gao, Zhengxing Lian, Fan Yang, Jun Chen, Fangqiang Wei, Xiao Xu, Zhikun Liu
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02406-y
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https://doi.org/10.1038/s41420-025-02406-y

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