Comparative transcriptomic analysis of mouse macrophages infected with live attenuated vaccine strains of Mycobacterium tuberculosis

Comparative transcriptomic analysis of mouse macrophages infected with live attenuated vaccine strains of Mycobacterium tuberculosis

The BCG vaccine has been used against tuberculosis (TB) for over a hundred years; however, it does not protect adults from pulmonary TB. To develop alternative vaccines against TB, we generated Mycobacterium tuberculosis H37Rv (Mtb)-derived vaccine strains by rationally deleting key virulent genes,...

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Bibliographic Details
Main Authors: Raja Veerapandian, Barbara Yang, Areanna Carmona, Melina J. Sedano, Victoria Reid, Rodrigo Jimenez, Jessica Chacon, Chinnaswamy Jagannath, Enrique I. Ramos, Shrikanth S. Gadad, Subramanian Dhandayuthapani
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
Mtb-vaccines
BCG
mouse
macrophages
RNA-sequencing
transcripts
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1583439/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1583439/full

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