THEM6 modulates carboplatin sensitivity by regulating ferroptosis through FDFT1 in triple-negative breast cancer

THEM6 modulates carboplatin sensitivity by regulating ferroptosis through FDFT1 in triple-negative breast cancer

Abstract Background Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis, as chemotherapy resistance leads to relapse in many patients. Carboplatin addition improves treatment response, but challenges persist. Methods To identify novel targets for TNBC, we analyzed diffe...

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Bibliographic Details
Main Authors: Yuexiang Zeng, Zhijie Xu, Juan Huang, Qiaoli Yi, Xi Chen, Jiayu Wang, Zhihao Du, Jian Tian, Yuanliang Yan
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Breast Cancer Research
Subjects:
Triple-negative breast cancer
Ferroptosis
Carboplatin
THEM6
FDFT1
Online Access:https://doi.org/10.1186/s13058-025-02078-7
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https://doi.org/10.1186/s13058-025-02078-7

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