Multicenter study correlating molecular characteristics and clinical outcomes of cancer cases with patient-derived organoids

Multicenter study correlating molecular characteristics and clinical outcomes of cancer cases with patient-derived organoids

Abstract Background 3D-spatial interaction between cancer cells influences tumor behavior, making it essential to replicate tumor structures for predicting patient outcomes. Methods We collected data from three multicenter prospective studies to evaluate the ability to establish Patient-Derived Orga...

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Main Authors: Paloma Navarro, Tatiana P. Grazioso, Arantzazu Barquín, Maria Barba, Mónica Yagüe, Carlos Millán, Irene López, Elena Sevillano, Miguel Quiralte, Paloma Fernández, Diego Losada, Eduardo Caleiras, Julia Calzas, Beatriz Jiménez, Sergio Ruiz-Llorente, Juan Justo, Félix Guerrero, Vital Hevia, Raquel Martín, Francisco José Pérez-Rodriguez, Julia Tejerina, Mario Prieto, Paula Comune, Juan Francisco Rodriguez-Moreno, Jesús García-Donás
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Precision Medicine
Patient-derived organoids
Drug screening
Online Access:https://doi.org/10.1186/s13046-025-03437-0
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https://doi.org/10.1186/s13046-025-03437-0

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