Fc-modification of anti-PcrV gene-encoded antibodies modulates complement-mediated killing of Pseudomonas aeruginosa

Fc-modification of anti-PcrV gene-encoded antibodies modulates complement-mediated killing of Pseudomonas aeruginosa

Pseudomonas aeruginosa is a high priority multi-drug-resistant (MDR) bacterial pathogen with increasing resistance against broad-spectrum antibiotics. Multiple efforts are ongoing to develop anti-pseudomonal vaccines however achieving meaningful outcomes has been challenging in human clinical trials...

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Main Authors: Jillian Eisenhauer, Spencer Dublin, Jihae Choi, Abigail R. Trachtman, Jacqueline D. Chu, David Custodio-Zegarra, Suman Bharti, Bhavya Bhardwaj, Shuangyi Bai, William T. Witt, Maria de la Paz Gutierrez, Sarah J. Miller, Kaitlyn Flowers, Trevor R. F. Smith, Bronwyn M. Gunn, Mariette Barbier, Elizabeth M. Parzych, David B. Weiner, Ami Patel
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
Pseudomonas aeruginosa
PcrV
complement system
DNA-encoded monoclonal antibody
type III secretion system
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1618297/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1618297/full

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