Microbiota alterations leading to amino acid deficiency contribute to depression in children and adolescents

Microbiota alterations leading to amino acid deficiency contribute to depression in children and adolescents

Abstract Background Major depressive disorder (MDD) in children and adolescents is a growing global public health concern. Metabolic alterations in the microbiota-gut-brain (MGB) axis have been implicated in MDD pathophysiology, but their specific role in pediatric populations remains unclear. Resul...

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Main Authors: Teng Teng, Fang Huang, Ming Xu, Xuemei Li, Lige Zhang, Bangmin Yin, Yuping Cai, Fei Chen, Luman Zhang, Jushuang Zhang, Aoyi Geng, Chengzhi Chen, Xiaofei Yu, Jing Sui, Zheng-Jiang Zhu, Kai Guo, Chenhong Zhang, Xinyu Zhou
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Microbiome
Subjects:
Depression
Amino acid
MGB axis
Children and adolescents
Microbiota
Glutaminergic synapse
Online Access:https://doi.org/10.1186/s40168-025-02122-w
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https://doi.org/10.1186/s40168-025-02122-w

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