Analysis of 1,25-dihydroxyvitamin D genomic action in human enteroids and colonoids reveals multiple regulatory effects of vitamin D in human intestinal physiology

Analysis of 1,25-dihydroxyvitamin D genomic action in human enteroids and colonoids reveals multiple regulatory effects of vitamin D in human intestinal physiology

IntroductionThe intestine has molecular and functional diversity across the proximal-distal and the crypt-villus axes, so it is imperative to determine the common and compartment-specific molecular actions of vitamin D. However, very little work on vitamin D mediated gene regulation has been done in...

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Bibliographic Details
Main Authors: Zachary K. Criss, Kali Deans-Fielder, James C. Fleet, Sylvia Christakos, Noah Shroyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Endocrinology
Subjects:
vitamin D
gene regulation
transcriptome
small intestine
colon
organoid
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1538463/full
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https://www.frontiersin.org/articles/10.3389/fendo.2025.1538463/full

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