Side by side comparison of NOTA and DOTA for conjugation efficiency, gallium-68 labeling, and in vivo biodistribution of anti-mesothelin sdAb A1-His

Side by side comparison of NOTA and DOTA for conjugation efficiency, gallium-68 labeling, and in vivo biodistribution of anti-mesothelin sdAb A1-His

Abstract Background Mesothelin is a glycoprotein overexpressed in various cancers, with limited expression in healthy tissues. The single-domain antibody (sdAb, or nanobody) A1-His has previously successfully been validated in mice for the SPECT imaging of mesothelin positive tumors following radiol...

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Main Authors: Émilien N’Guessan, Sandrine Bacot, Florian Raes, Julien Leenhardt, Thibault Guenard, Laurent Dumas, Catherine Ghezzi, Daniel Fagret, Charlotte Lombardi, Alexis Broisat, Mitra Ahmadi
Format: Article
Language:English
Published: SpringerOpen 2025-08-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
DOTA
NOTA
Gallium-68
Radiolabeling
Theranostics
sdAb
Online Access:https://doi.org/10.1186/s41181-025-00380-5
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https://doi.org/10.1186/s41181-025-00380-5

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