Phenotypic and genomic changes in enteric Klebsiella populations during long-term ICU patient hospitalization: the role of RamR regulation

Phenotypic and genomic changes in enteric Klebsiella populations during long-term ICU patient hospitalization: the role of RamR regulation

ABSTRACT Acquired antimicrobial resistance and metabolic changes are central for bacterial host adaptation during the long-term hospitalization of patients. We aimed to analyze the genomic and phenotypic evolution of enteric Klebsiella populations in long-term intensive care unit (ICU) patients. Wee...

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Main Authors: Benedicte Langlois, Francois Guerin, Christophe Isnard, Clement Gakuba, Damien Du Cheyron, Jean-Christophe Giard, Sylvain Brisse, Simon Le Hello, Francois Gravey
Format: Article
Language:English
Published: American Society for Microbiology 2024-12-01
Series:mSphere
Subjects:
Klebsiella variicola
long-term carriage
intensive care units
population dynamic
RamR
host adaptation
Online Access:https://journals.asm.org/doi/10.1128/msphere.00704-24
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https://journals.asm.org/doi/10.1128/msphere.00704-24

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