Early preclinical development of Mycobacterium tuberculosis amino acid biosynthesis pathway inhibitor DRILS-1398 as a potential anti-TB drug

Early preclinical development of Mycobacterium tuberculosis amino acid biosynthesis pathway inhibitor DRILS-1398 as a potential anti-TB drug

Summary: The search for new anti-tubercular agents is vital for the fight against Mycobacterium tuberculosis, particularly given the rise of drug-resistant strains. DRILS-1398, a pyrazolo[4,3-d]pyrimidine derivative, was discovered as a potent inhibitor of M.tb chorismate mutase (M.tb-CM) with an IC...

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Main Authors: Deepesh Biswas, Rebecca Kristina Edwin, K. Shiva Kumar, Anwar Alam, Dhiraj Kumar, Sandipan Chakraborty, Gopalakrishnan Bulusu, Farhan Jalees Ahmad, Gautham G. Shenoy, Lakshyaveer Singh, Mansi Agarwal, Fouzia Siraj, Srinivas Oruganti, Parimal Misra, Nasreen Zafar Ehtesham, Manojit Pal, Seyed Ehtesham Hasnain
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Biological sciences
Medical Microbiology
Microbiology
Natural sciences
Pharmacology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225007989
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