Сасо-2 INTESTINAL PERMEABILITY AND Pgp-AFFINITY OF PHOSPHAZIDE
In this work the intestinal permeability of phospazide in vitro was investigated using Caco-2 cell model in apical-basolateral (A-B) and basolateral-apical (B-A) directions as well as with the option of adding of P-glycoprotein (Pgp) inhibitor cyclosporine A. The following standard substances were u...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/522 |
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| _version_ | 1849243910719668224 |
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| author | D. Yu. Grebenkin Ya. M. Stanishevskiy I. E. Shohin A. M. Stoinova M. A. Karpova A. G. Koryakova A. V. Ryabova B. V. Brovchenko A. A. Smirnov |
| author_facet | D. Yu. Grebenkin Ya. M. Stanishevskiy I. E. Shohin A. M. Stoinova M. A. Karpova A. G. Koryakova A. V. Ryabova B. V. Brovchenko A. A. Smirnov |
| author_sort | D. Yu. Grebenkin |
| collection | DOAJ |
| description | In this work the intestinal permeability of phospazide in vitro was investigated using Caco-2 cell model in apical-basolateral (A-B) and basolateral-apical (B-A) directions as well as with the option of adding of P-glycoprotein (Pgp) inhibitor cyclosporine A. The following standard substances were used: ranitidine and propranolol. Papp values of test and standard substances were obtained. The obtained data were compared with the values (A) log P for the test and standard substances. According the results of this study, the phosphatide presumably has a low intestinal permeability in terms of BCS. The affinity of phosphazide for the efflux transporter Pgp was demonstrated. |
| format | Article |
| id | doaj-art-965254296f2a483ebde6c9d0773cb890 |
| institution | Kabale University |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-965254296f2a483ebde6c9d0773cb8902025-08-20T03:59:20ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0104238242522Сасо-2 INTESTINAL PERMEABILITY AND Pgp-AFFINITY OF PHOSPHAZIDED. Yu. Grebenkin0Ya. M. Stanishevskiy1I. E. Shohin2A. M. Stoinova3M. A. Karpova4A. G. Koryakova5A. V. Ryabova6B. V. Brovchenko7A. A. Smirnov8Institute of Biochemical Technology and Nanotechnology Peoples' Friendship University of Russia; ExacteLabs CompanyInstitute of Biochemical Technology and Nanotechnology Peoples' Friendship University of RussiaCenter of Pharmaceutical Analytics LtdInstitute of Biochemical Technology and Nanotechnology Peoples' Friendship University of RussiaLLC «Research Institute ChemRar»LLC «Research Institute ChemRar»ExacteLabs CompanyLLC «AZT PHARMA K.B.»LLC «AZT PHARMA K.B.»In this work the intestinal permeability of phospazide in vitro was investigated using Caco-2 cell model in apical-basolateral (A-B) and basolateral-apical (B-A) directions as well as with the option of adding of P-glycoprotein (Pgp) inhibitor cyclosporine A. The following standard substances were used: ranitidine and propranolol. Papp values of test and standard substances were obtained. The obtained data were compared with the values (A) log P for the test and standard substances. According the results of this study, the phosphatide presumably has a low intestinal permeability in terms of BCS. The affinity of phosphazide for the efflux transporter Pgp was demonstrated.https://www.pharmjournal.ru/jour/article/view/522bcspermeabilitycaco-2phosphazide |
| spellingShingle | D. Yu. Grebenkin Ya. M. Stanishevskiy I. E. Shohin A. M. Stoinova M. A. Karpova A. G. Koryakova A. V. Ryabova B. V. Brovchenko A. A. Smirnov Сасо-2 INTESTINAL PERMEABILITY AND Pgp-AFFINITY OF PHOSPHAZIDE Разработка и регистрация лекарственных средств bcs permeability caco-2 phosphazide |
| title | Сасо-2 INTESTINAL PERMEABILITY AND Pgp-AFFINITY OF PHOSPHAZIDE |
| title_full | Сасо-2 INTESTINAL PERMEABILITY AND Pgp-AFFINITY OF PHOSPHAZIDE |
| title_fullStr | Сасо-2 INTESTINAL PERMEABILITY AND Pgp-AFFINITY OF PHOSPHAZIDE |
| title_full_unstemmed | Сасо-2 INTESTINAL PERMEABILITY AND Pgp-AFFINITY OF PHOSPHAZIDE |
| title_short | Сасо-2 INTESTINAL PERMEABILITY AND Pgp-AFFINITY OF PHOSPHAZIDE |
| title_sort | сасо 2 intestinal permeability and pgp affinity of phosphazide |
| topic | bcs permeability caco-2 phosphazide |
| url | https://www.pharmjournal.ru/jour/article/view/522 |
| work_keys_str_mv | AT dyugrebenkin saso2intestinalpermeabilityandpgpaffinityofphosphazide AT yamstanishevskiy saso2intestinalpermeabilityandpgpaffinityofphosphazide AT ieshohin saso2intestinalpermeabilityandpgpaffinityofphosphazide AT amstoinova saso2intestinalpermeabilityandpgpaffinityofphosphazide AT makarpova saso2intestinalpermeabilityandpgpaffinityofphosphazide AT agkoryakova saso2intestinalpermeabilityandpgpaffinityofphosphazide AT avryabova saso2intestinalpermeabilityandpgpaffinityofphosphazide AT bvbrovchenko saso2intestinalpermeabilityandpgpaffinityofphosphazide AT aasmirnov saso2intestinalpermeabilityandpgpaffinityofphosphazide |