Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts

Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts

Abstract Fibrosis is a common outcome of numerous pathologies, including chronic kidney disease (CKD), a progressive renal function deterioration. Current approaches to target activated fibroblasts, key effector contributors to fibrotic tissue remodeling, lack specificity. Here, we report Gucy1α1 as...

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Main Authors: Valeria Rudman-Melnick, Davy Vanhoutte, Kaitlynn Stowers, Michelle Sargent, Mike Adam, Qing Ma, Anne Karina T. Perl, Alexander G. Miethke, Ashley Burg, Tiffany Shi, David A. Hildeman, E. Steve S. Woodle, J. Matthew Kofron, Prasad Devarajan
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Kidney fibrosis
CKD
Multiorgan fibroblast marker
Online Access:https://doi.org/10.1038/s41598-024-80930-0
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https://doi.org/10.1038/s41598-024-80930-0

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