Enhancing the discriminatory power of polygenic scores for ADHD and autism in clinical and non-clinical samples

Abstract Background Polygenic scores (PGS) are widely used in psychiatric genetic associations studies due to their predictive power for focal outcomes. However, they lack discriminatory power, in part due to the high degree of genetic overlap between psychiatric disorders. The lack of prediction sp...

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Bibliographic Details
Main Authors: James J. Li, Quanfa He, Stephen Dorn, Zihang Wang, Qiongshi Lu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Neurodevelopmental Disorders
Subjects:
Online Access:https://doi.org/10.1186/s11689-025-09620-w
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